PBC in the News

Summary News

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• Rising awareness and media coverage of liver diseases, particularly PBC, including expert discussions and patient stories on various platforms.
• Promising clinical trial results for new PBC treatments such as linerixibat, seladelpar (Livdelzi), and elafibranor (Iqirvo), showing improvements in symptoms like itch and fatigue.
• Regulatory progress with multiple approvals and conditional authorizations of PBC treatments across Europe, the US, and the UK (e.g., Livdelzi, Iqirvo).
• Ongoing research into the mechanisms and associated conditions of PBC, including links to lymphoma, systemic sclerosis, and gut microbiota.
• Growing investment and milestone payments in the PBC drug development sector, reflecting commercial interest and expanding treatment options.
• Studies highlighting the importance of early diagnosis, personalized treatment plans, and quality of life improvements for PBC patients.
• Concerns over safety and effectiveness of existing treatments, with regulatory bodies declining or revoking approvals (e.g., Ocaliva).
• Educational efforts through art, patient stories, and physician guidance to support awareness and understanding of rare liver diseases like PBC.

News Articles

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10/09/2026 Gilead Helps Make the Unseen Parts of Primary Biliary Cholangitis Visible with Film and Poetry - gilead.com

10/09/2026 Gut microbial metabolite imidazole propionate drives sclerosing cholangitis through p38 signaling - Bioengineer.org

09/09/2026 Livdelzi accepted in Scotland for treatment of PBC - PharmaTimes

07/09/2026 Sleep disorders in primary biliary cholangitis: A prospective analysis of clinical and patient-reported outcomes - www.elsevier.com

04/09/2026 Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling - Nature

01/09/2026 Patients Suffering from Primary Biliary Cholangitis (PBC) Push Back on Stigma - Yahoo Finance

24/08/2026 PBC patients see disease markers rebound after trial as Korea reimbursement lags - Korea Biomedical Review

18/08/2026 Primary Biliary Cholangitis: A New Treatment Paradigm - Gastroenterology & Endoscopy News

30/07/2026 Lynavoy recommended for EU approval by the CHMP - PharmaTimes

29/07/2026 A Dual Time Window-driven Strategy to Optimize Primary Biliary Cholangitis Treatment via Alkaline Phosphatase Normalization - EurekAlert!

29/07/2026 A dual time window-driven strategy to optimize primary biliary cholangitis treatment via alkaline phosphatase normalization - EurekAlert!

28/07/2026 Efficacy, symptoms, and safety of second-line PBC therapies: a network meta-analysis - Frontiers

28/07/2026 Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome With Limited Systemic Sclerosis - cureus.com

28/07/2026 Primary Biliary Cholangitis in the Middle East: A Review of Current Challenges and Treatment Approaches - cureus.com

28/07/2026 EMA Supports New Oral Treatment for PBC Itch - Medscape

24/07/2026 Linerixibat secures CHMP backing as first targeted therapy for cholestatic pruritus in primary biliary cholangitis. - AllSci

23/07/2026 New approaches to treating a rare disease affecting the liver - UB - Universitat de Barcelona

22/07/2026 What To Eat To Help Manage Primary Biliary Cholangitis - Cleveland Clinic Health Essentials

13/07/2026 Improving Disease Management in Primary Biliary Cholangitis - emjreviews.com

13/07/2026 Looking Beyond the Numbers: Addressing the Full Burden of PBC - emjreviews.com

13/07/2026 ELSPIRE: Elafibranor Achieves Robust ALP Normalization in PBC - Medical Professionals Reference

13/07/2026 Elafibranor Achieves 85% ALP Normalization in Phase 3b ELSPIRE Trial for PBC - HCPLive

13/07/2026 Immune and Cholestatic Liver Disease at the EASL Congress 2026 - emjreviews.com

09/07/2026 Saroglitazar and the Evolving PBC Treatment Landscape, With Raj Vuppalanchi, MD - HCPLive

07/07/2026 Resistant primary biliary cholangitis: treatment with Elafibranor - Clínica FEHV

06/07/2026 Liver–kidney crosstalk in primary biliary cholangitis: insights into the mechanisms of renal involvement - Frontiers

03/07/2026 Nearly 1 in 10 Patients With Primary Biliary Cholangitis Have Chronic Kidney Disease - Medscape

01/07/2026 Large VA study reveals hidden liver damage in US military veterans - Liver Disease News

30/06/2026 Selective PPARα Modulator "K-808" (Pemafibrate) Granted "Breakthrough Therapy" Designation by the U.S. Food and Drug Administration (FDA) As a Treatment for Primary Biliary Cholangitis - PR Newswire

24/06/2026 Primary Biliary Cholangitis Pipeline Shows Potential with Active Contributions from 20+ Key Companies | DelveInsight - Barchart.com

17/06/2026 Scientists ID, test 2 immune proteins as possible therapeutic targets in PBC - Liver Disease News

11/06/2026 Looking Beyond ALP Response in PBC With Saroglitazar, With Raj Vuppalanchi, MD - HCPLive

10/06/2026 Saroglitazar Targets Bile Acid Dysregulation, Inflammation in PBC, With Raj Vuppalanchi, MD - HCPLive

09/06/2026 Seladelpar (Livdelzi) raises the bar for primary biliary cholangitis treatment - 2 Minute Medicine

08/06/2026 NICE approves seladelpar for primary biliary cholangitis - The Pharmaceutical Journal

05/06/2026 Seladelpar Given Go-Ahead by NICE for PBC Treatment - Medscape

03/06/2026 Gilead eyes PBC expansion for Livdelzi on positive one-year data - Clinical Trials Arena

03/06/2026 Livdelzi lowers liver damage marker across PBC trials, data show - Liver Disease News

03/06/2026 2MM: Pharma Roundup – Pfizer’s $10.5B Innovent oncology partnership, Guselkumab (Tremfya) gains a broader psoriatic arthritis label, Venetoclax (Venclyxto) expands first-line CLL options, and Seladelpar (Livdelzi) advances in primary biliary cholangitis - 2 Minute Medicine

02/06/2026 Gilead touts Phase III win that could put Livdelzi on track for wider PBC label - FirstWord Pharma

02/06/2026 Gilead's Livdelzi scores in rare liver disease trial, portending use in broader patient population - fiercepharma.com

01/06/2026 Saroglitazar Boosts Response Rates in Primary Biliary Cholangitis - MedPage Today

28/05/2026 Zydus Therapeutics New Drug Application (NDA) for Saroglitazar to Treat Primary Biliary Cholangitis (PBC) Granted Priority Review by the US FDA - PR Newswire

28/05/2026 FDA Grants Priority Review to Saroglitazar NDA for Primary Biliary Cholangitis - HCPLive

28/05/2026 Studies at EASL Congress Could Reshape Liver Disease Prevention, Diagnosis and Care - hepmag.com

27/05/2026 Oral ABI-6250 may move into Phase 2 clinical testing for PBC and PSC - Liver Disease News

27/05/2026 Dear Doctor: Two rare, deadly diseases that have some similarities, but I can’t find info about one - Syracuse.com

21/05/2026 Overlap Syndrome Between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in a Seven-Year-Old Child: A Case Report - cureus.com

21/05/2026 Driving Progress in Rare Liver Disease: Ipsen at EASL Congress 2026 - Ipsen

19/05/2026 Treatment Sequencing in Primary Biliary Cholangitis - Medscape Reference: Drugs, Diseases & Medical Procedures

18/05/2026 Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications - Frontiers

18/05/2026 Addressing the Symptom Burden of Primary Biliary Cholangitis - Medscape Reference: Drugs, Diseases & Medical Procedures

12/05/2026 Can Hypnosis Help Women With Primary Biliary Cholangitis and Fatigue? Read the Study in the May Issue of The American Journal of Gastroenterology | Newswise - Newswise

05/05/2026 Fenofibrate-UDCA Combination Therapy Safe and Effective for Primary Biliary Cholangitis - Cleveland Clinic

05/05/2026 Primary goal achieved in Mirum’s Phase IIb trial of volixibat - Clinical Trials Arena

14/04/2026 Unraveling immunological heterogeneity in recalcitrant AIH-PBC/PSC overlap syndromes: from molecular crosstalk to precision therapeutics - Frontiers

10/04/2026 Early MRCP surveillance for recurrent primary sclerosing cholangitis after liver transplantation: a prospective imaging study - Nature

06/04/2026 Baseline Alkaline Phosphatase Impacts Response Rates in Primary Biliary Cholangitis: Exploring Response to Elafibranor in ELATIVE - Wiley Online Library

03/04/2026 Seladelpar Improved Itch, Itch-Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial - Wiley Online Library

02/04/2026 Molecular mechanisms underlying T cell subset imbalance and precision therapeutic targets in primary biliary cholangitis - Frontiers

31/03/2026 The impact of male sex on outcomes in primary biliary cholangitis - Nature

30/03/2026 FDA approves GSK's Lynavoy for cholestatic pruritus in primary biliary cholangitis - AllSci

25/03/2026 Study indicates which PBC patients may see liver function recovery - Liver Disease News

23/03/2026 FDA Approves Lynavoy for PBC-Associated Pruritus - Gastroenterology & Endoscopy News

20/03/2026 Protect Your Well-Being With Primary Biliary Cholangitis - Everyday Health

20/03/2026 FDA approves treatment for debilitating itch in rare liver disease - Managed Healthcare Executive

19/03/2026 FDA Approves Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis - AJMC

19/03/2026 FDA approves first drug for itch due to primary biliary cholangitis - FirstWord Pharma

19/03/2026 FDA Approves Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis - Pharmacy Times

19/03/2026 FDA Approves Linerixibat (Lynavoy) As First Treatment for Cholestatic Pruritus in PBC - HCPLive

09/03/2026 Alfasigma bets up to $690M on GSK’s late-stage PBC itch drug ahead of FDA decision - European Biotechnology Magazine

09/03/2026 Alfasigma Pays $300M for Rights to GSK Rare Liver Disease Drug On Track for FDA Decision - MedCity News

04/03/2026 New PBC therapy found to reduce liver scarring after 1 year in US trial - Liver Disease News

03/03/2026 COUR Pharma reports one-year Phase IIa data for PLGA nanoparticle drug in primary biliary cholangitis - AllSci

02/03/2026 Impact of Alkaline Phosphatase Normalization on... : American Journal of Gastroenterology - Lippincott Home

19/02/2026 Statin Use Linked to Lower Hepatic Decompensation Risk in Primary Biliary Cholangitis - Medscape

17/02/2026 Osteoporosis in primary biliary cholangitis: from cholestasis to fracture prevention - Termedia

16/02/2026 The Safety of PPAR Agonists in PBC: Reviewing Recent Trial Data - HCPLive

11/02/2026 Shifting the Clinical Conversation Around Statins in PBC, With Jonggi Choi, MD, PhD - HCPLive

11/02/2026 Primary biliary cholangitis–associated osteoporosis: contemporary review of pathogenesis and management - EurekAlert!

11/02/2026 Noninvasive combo tests for liver damage could replace biopsies in PBC - Liver Disease News

10/02/2026 Statins and Improved Long-Term Liver Outcomes in PBC, With Jonggi Choi, MD, PhD - HCPLive

28/01/2026 IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury - Wiley Online Library

28/01/2026 Could the sun lower PBC risk? Study explores benefits of UV exposure. - Liver Disease News

26/01/2026 Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health - HCPLive

22/01/2026 Closing Gaps in PBC Care With Emerging and Established Second-Line Treatments - HCPLive

14/01/2026 Diagnostic potential of salivary biomarkers for primary biliary cholangitis: a systematic review - Frontiers

02/01/2026 Seladelpar reduced pruritus in PBC as early as ‘first month, and persisted’ - Healio

02/01/2026 Cholangitis in 2025: Year in Review - HCPLive

23/12/2025 Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization | Scientific Reports - Nature

22/12/2025 Treating primary biliary cholangitis - Mayo Clinic Press

17/12/2025 Compound found in honey reduced inflammation in PBC mice in lab - Liver Disease News

10/12/2025 Major Developments in the PBC Pruritus Treatment Pipeline - Gastroenterology & Endoscopy News

27/11/2025 Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation - Nature

19/11/2025 Blood group A linked to a higher risk of primary biliary cholangitis - News-Medical

11/11/2025 Long-Term Efficacy and Symptom Relief With Elafibranor in PBC, With Andreas Kremer, MD, PhD - HCPLive

07/11/2025 Volixibat Improves Fatigue and Sleep in Patients With Primary Biliary Cholangitis - HCPLive

27/10/2025 Exploring primary biliary cholangitis - Healio

22/10/2025 Trends in Primary Biliary Cholangitis: Prospective Cohort Study From the European Reference Network Registry (R-LIVER) - Wiley Online Library

10/10/2025 Bezafibrate for primary biliary cholangitis: time to act on the evidence - Nature