PBC in the News

Summary News

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• Rising awareness and media coverage of liver diseases, particularly PBC, including expert discussions and patient stories on various platforms.
• Promising clinical trial results for new PBC treatments such as linerixibat, seladelpar (Livdelzi), and elafibranor (Iqirvo), showing improvements in symptoms like itch and fatigue.
• Regulatory progress with multiple approvals and conditional authorizations of PBC treatments across Europe, the US, and the UK (e.g., Livdelzi, Iqirvo).
• Ongoing research into the mechanisms and associated conditions of PBC, including links to lymphoma, systemic sclerosis, and gut microbiota.
• Growing investment and milestone payments in the PBC drug development sector, reflecting commercial interest and expanding treatment options.
• Studies highlighting the importance of early diagnosis, personalized treatment plans, and quality of life improvements for PBC patients.
• Concerns over safety and effectiveness of existing treatments, with regulatory bodies declining or revoking approvals (e.g., Ocaliva).
• Educational efforts through art, patient stories, and physician guidance to support awareness and understanding of rare liver diseases like PBC.

News Articles

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26/10/2026 Primary Sclerosing Cholangitis Pipeline Update 2026: Clinical - openPR.com

26/10/2026 Seronegative Autoimmune Hepatitis With Primary Biliary Cholangitis Features Presenting As Acute Biliary Disease: A Case Report - Cureus

17/10/2026 Zydus Presents Geographic Subgroup Analysis of Saroglitazar Trial in Primary Biliary Cholangitis - Machine Maker

07/09/2026 Sleep disorders in primary biliary cholangitis: A prospective analysis of clinical and patient-reported outcomes - www.elsevier.com

22/07/2026 What To Eat To Help Manage Primary Biliary Cholangitis - Cleveland Clinic Health Essentials

19/05/2026 Treatment Sequencing in Primary Biliary Cholangitis - Medscape Reference

23/12/2025 Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization | Scientific Reports - Nature

10/10/2025 Bezafibrate for primary biliary cholangitis: time to act on the evidence - Nature

01/09/2025 Beyond tired: Understanding fatigue in Primary Biliary Cholangitis - Ipsen

28/08/2024 Primary biliary cholangitis - The Lancet

21/05/2024 Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization - Nature

16/11/2023 Clinical trial results suggest potential new treatment for primary biliary cholangitis - UC Davis Health

13/11/2023 Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis - NEJM

06/09/2023 Liverace Explains Primary Biliary Cholangitis (PBC) - American Liver Foundation

14/11/2022 Prevalence and impact of Sjögren's syndrome in primary biliary cholangitis: a systematic review and meta-analysis - www.elsevier.com

01/12/2021 Primary Biliary Cholangitis - American Liver Foundation

08/08/2019 Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort - Nature

06/06/2018 A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis - NEJM

23/03/2018 Primary Biliary Cirrhosis: Clinical, Pathologic, and Helical CT Findings in 53 Patients | Radiology - RSNA Journals

18/08/2016 A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis - NEJM